Inhibitory Effects of Oxidized Low - density Cholesterol Acyltransferase
نویسندگان
چکیده
of ox-LDL, (ii) This inhibitory effect was dose-dependent and was re]ated to the degree of oxidation of LDL, (iii) As this inhibitoTy effbct was not prevented by antioxidants, it is suggested that it does not occur via oxidation of substrate HDL These results suggest that cholesterol reyerse-translK)rt via HDL may be affbcted by ox-I.DL and they are noteworth}' in suggesting a new physio]ogical function for ox-I.DL.'
منابع مشابه
Association of Lecithin Cholesterol Acyltransferase rs5923 Polymorphism in Iranian Individuals with Extremely Low High-Density Lipoprotein Cholesterol: Tehran Lipid and Glucose Study
Background: The serum concentration of high-density lipoprotein cholesterol (HDL-C) is one of the important heritable risk factors for cardiovascular disease and is a target for therapeutic intervention. In this study, we aimed to evaluate the effects of lecithin cholesterol acyltransferase (LCAT) gene polymorphism rs5923 on LCAT enzyme activity and serum HDL-C concentration. Methods: The study...
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